According To A New Study, A Calorie Reduced Diet Can Not Only Delay The Development Of Metabolic Diseases, But Also Have A Positive Impact On The Immune System The Researchers Show That This Effect Is Caused By The Altered Intestinal Microbiome, Which Slows The Deterioration Of The Immune System In Old Age (Immune Aging). Published In The Microbiological Research Group( Https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01249-4 ) 》In The Magazine.
About 2 Billion People Around The World Are Overweight. Obesity Increases The Risk Of High Blood Pressure, Heart Attack Or Type 2 Diabetes. It Also Causes Inflammation In The Body, Weakening The Immune System Through The Accumulation Of Specific Memory T And B Cells. This Process, Called Aging, Is Related To The Immune System.
For Obese People, A Low Calorie Diet Can Delay The Development Of Metabolic Diseases, Such As Type 2 Diabetes. In Addition, Such A Diet Is Good For The Immune System. However, It Is Unclear How These Positive Effects Are Brought About And What Function The Intestinal Microbiota Plays In This Process. In A New Study, Researchers Now Explore The Relationship Between Calorie Reducing Diets, Microbiota, Metabolism And The Immune System.
To This End, They First Analyzed How A Very Low Calorie Diet (800 Kcal / Day For 8 Weeks) Affected The Intestinal Microbiome Of An Obese Woman. In The Next Step, The Researchers Transplanted The Intestinal Microbiota Before And After Dietary Intervention Into Sterile Mice To Establish A Sterile Mouse Model. "In This Way, We Can Determine The Only Effect Of Dietary Gut Microbiota On Metabolism And Immune System," Said Reiner Jumpertz Von Schwartzenberg, The Study's Author, A Partner Of The German Diabetes Research Center (DZD) And A Scientist At The Helmholtz Diabetes Institute For Diabetes Research And Metabolic Diseases In Munich, University Of Tubingen He Led The Study With Hans Dieter Volk And Joachim Spranger Of Charit é.
By Transplanting Diet Changing Microbiota, Glucose Metabolism Is Improved And Fat Deposition Is Reduced. In Addition, The Mass Spectrometer Showed That The Levels Of Specific Memory T And B Cells Also Decreased. "This Suggests That Immune Aging Is Delayed," Said Julia Sbierski Kind, The Study's Lead Author
"These Findings Suggest That The Positive Effects Of A Low Calorie Diet On Metabolism And The Immune System Are Mediated Through The Intestinal Microbiome. However, The Study's Authors Emphasize That So Far, The Survey Has Studied Only One Person's Microbiome And That More Subjects Must Be Repeated To Confirm The Results. In The Long Run, These New Findings May Also Have Implications For Medical Practice," Sbierski Kind Said "A Better Understanding Of The Complex Interactions Between Diet, Microbiome And Immune System May Lay The Foundation For The Development Of New Microbial Based Therapies To Treat Metabolic And Immune Diseases," Jumpertz Von Schwartzenberg Said