In A New Research Paper Published In The Journal Cell On April 29, 2022, Stanford University Researchers Sternly Warned That There Is A Close Positive Correlation Between Regular Marijuana Use And An Increased Risk Of Heart Attack** Specifically, Tetrahydrocannabinol (THC) Can Cause Inflammation Of Vascular Cells, So The Researchers Strongly Urge Marijuana Users To Pay Attention To The Potential Cardiovascular Risk.
(from: Stanford Medicine | news Center)
It Is Reported That The Study First Analyzed The Data Of About 500000 People To Reveal The Relationship Between Marijuana Smoking And Heart Attack.
After Controlling For Factors Such As Age, Gender And Weight, The Data Showed That Compared With The Control Group Who Did Not Smoke Marijuana, The Experimental Group Who Smoked More Than Once A Month Was Much More Likely To Suffer From Heart Disease Before The Age Of 50**
Next, Researchers Began To Investigate How Cannabis Increased This Risk, And Soon Focused On Tetrahydrocannabinol (THC).
**It Was Found That This Component Did Boost The Inflammation Of Human Endothelial Cells Cultured In The Laboratory - Inflammation Of Endothelial Cells (cells Inside Blood Vessels And Heart) Is A Key Indicator Of Heart Disease.
"Marijuana Has Significant Adverse Effects On The Cardiovascular System," Said Study Co-author Mark Chandy.
As More And More States In The United States Legalize Marijuana, We Expect To See A Sharp Rise In Heart Disease And Stroke Cases In The Next Few Years.
Studies On Human Cells And Mice Have Clearly Outlined How Thc Exposure Triggers A Destructive Molecular Cascade In Blood Vessels - It Is Definitely Not A 'benign' Component Of A 'drug'.
The Last Part Of The Study Is To Find Molecules That Can Help Block The Pro-inflammatory Properties Of THC Without Affecting Its Psychoactive Effects.
Considering That The Main Function Of THC Is To Bind To CB1 Receptor, Researchers Thought Of Screening A Large Number Of Molecules Known To Bind To CB1 And Block The Effect Of THC With The Power Of Machine Learning (ML).
(from: cell00443-3))
One Of The Prominent Molecules Is A Natural Substance Called Genistein The Genistein Found In Soybeans Cannot Effectively Penetrate The Blood-brain Barrier.
The Researchers Speculate That It May Be Able To Block The Inflammatory Effect Of THC On Endothelial Cells And Maintain The Psychoactive Effect Of THC On The Brain. Subsequent Mouse Studies Also Confirmed This Hypothesis.
Experiments Show That Fuel Genistein Can Reduce Endothelial Dysfunction In Mice Without Hindering The Effect Of THC On Animal Central Nervous System.
Chandy Added: Although We Have Not Seen Any Obstacles To The Normal Analgesic / Sedative Effects Of THC In Mice, The Study Suggests The Potential Medicinal Properties Of Cannabis To Some Extent.
Genistein May Be A Safer Drug Than Previous CB1 Antagonists, And It Has Been Used As A Nutritional Supplement.
Previous Studies Have Shown That 99% Of Genistein Will Be Blocked By The Blood-brain Barrier, So It Should Not Cause Special Adverse Side Effects.
As For The More Precise Effect Of Genistein On Marijuana Users And Cardiovascular Risk, More Thorough Clinical Trials Are Still Needed.
In Addition, Another Key Element Contained In Cannabis (CBD), May Also Have Anti-inflammatory Effects Against The Potential Cardiovascular Risk Of THC**
Previous Studies On The Negative Mental Effects Of Cannabis Have Shown That The Increase Of THC Content In Modern Cannabis Varieties May Lead To A Higher Incidence Of Adverse Mental Health Problems.
On The Other Hand, CBD Is A Known Antipsychotic Drug. Therefore, It May Play An Important Role In Balancing The Levels Of These Two Cannabinoids In Easy-to-use Cannabis Strains.